Widget Image

I receive in Florence, Prato and Milan

Matteotti Medical Group
Viale Giacomo Matteotti, 42
50132 - Florence (FI)
Telephone: 055 570224
Florence Castello
Villa Donatello
Via Attilio Ragionieri, 101
50019 - Sesto Fiorentino (FI)
Telephone: 055 50975
Studi Medici Life
Viale della Repubblica, 141
59100 - Prato (PO)
Telephone: 0574 583501
Columbus Clinic Center
Via Michelangelo Buonarroti, 48
20145 - Milan (MI)
Telephone: 02 480 801

Peyronie's disease
Specialized centers Milan

Peyronie's disease specialized centers Milan

To diagnose, cure and treat Peyronie’s disease, there is no shortage of specialized Milan centers. Although this is a condition that has been described and known for many centuries now, it is still the subject of study and research today. This is because it is widespread, and the number of people who are afflicted with it is constantly growing. Suffice it to say that in Italy alone, as much as 7 percent of the male population is affected. The age group most affected by its symptoms is between the ages of 50 and 70. Older men, then, but not only. The triggers appear to be traumatic in origin. When the penis undergoes traumatic events, fibrosis-cicatricial tissue may be generated, leading to the occurrence of Peyronie’s disease.

This unique morphological condition affects mostly in the 40-60 age group. Diabetics and hypertensives are more exposed to it, and the famous
Peyronie’s disease
, inevitably leads to degeneration into the pathology of the
curved penis
. Whatever the nature and triggers, it is a rather aesthetically embarrassing disease. The problem, however, is not just aesthetic, rather functional.

In fact, when the angle of curvature of the penis is too marked, the patient may experience serious difficulties during the sexual act. The curvature can cause pain to the partner during the act of penetration, so much so that it is very painful, if not impossible to consummate intercourse.

Peyronie's disease: what it is

It was first observed in the remote 1550s by an Italian physician Antonio. It was not until 1743, however, that it was first described, thanks to the studies and analysis of a French surgeon serving in the army of Louis XV, François Gigot de La Peyronie, who gave the disease its name.

Today, this disease continues to be the subject of study and research, although the correlation between Peyronie’s Disease has been verified,
curved penis
and traumatic events suffered by the male organ. Trauma resulting from sexual intercourse, or occurring under accidental circumstances, such as traffic accidents, workplace accidents, or sports injuries.

The disease is manifested by the formation of fibrous-cicatricial tissue within the corpora cavernosa of the penis. In fact, the central body of the penis is traversed by two distinct tubular structures, which are located within a cavernous structure. The tubular sections are located in the dorsal part and on the upper side of the central body, while in the lower part, i.e., the ventral part, there is a spongy body, crossed by the urethra.

The fibrotic cluster forms in the corpora cavernosa, those that swell with blood at the time of erection and allow the penis to rise. The mass that is created thus prevents the penis from erecting, also causing pain for both the patient and their partner during sexual intercourse.

Peyronie's disease specialized centers Milan

To combat Peyronie’s Disease, specialized centers Milan offers a range of cutting-edge treatments and specialist care in this specific area. Research is always evolving, but a number of effective treatments have already been developed, both pharmacologically and surgically.

Before adopting any treatment an andrologist, assesses a number of factors:

  1. penile curvature
  2. Stability or instability of the penile curvature
  3. The pains and complications arising from the sexual act
  4. painful or non-painful erections
  5. Ability to have and/or maintain an erection throughout sexual intercourse

Drug treatments

When penile curvature is mild, symptoms are moderate, and Peyronie’s disease does not greatly affect the ability to have sex, drug treatment is usually opted for.This type of treatment includes those based on:
  • Verapamil
  • Interferon
  • Collagenase of Clostridium histolyticum


This is a drug capable of disrupting the production of collagen, a protein directly responsible for the formation of fibrous-catenotic tissue.


Other protein believed to block the production of fribotic plaque. Use would allow the patient’s penile curvature to worsen.

Collagenase of Clostridium histolyticum

Collagenesis is a particular enzyme that can deconstruct into small pieces, collagen. Collagenesis succeeds in cutting the peptide bonds in collagen, thereby succeeding in reducing, substantially, the curvature of the penis.The enzyme acts on the distribution of extracellular structures. Their target is the connective tissue of muscle cells and in other organs of the body. This is a completely noninvasive, nonsurgical procedure that requires only a small injection of localized anesthesia to perform the actual injection. The results are excellent and the postoperative risks virtually zero.

Surgical treatments

Surgery is the treatment of choice for urologists e andrologists in cases where penile curvature is marked and very noticeable. When normal sexual activity is impaired, or even impossible to exercise then to counter Peyronie’s disease, Milan centers opt for surgery.These include:
  1. intervention of Nesbit
  2. triple incision-excision-transplant surgery
  3. implantation of a penile prosthesis

Nesbit Intervention

This is a type of surgery that involves making a circular incision, below the foreskin, that highlights the corpus cavernosum. With this technique, part of the healthy tissue, as opposed to the fibrous-cicatricial tissue, is removed. A practice that counts some disadvantages: the length of the penis is reduced and the risks of erectile dysfunction are increased.

Triple incision-excision-transplantation surgery

This is an invasive and complicated technique, adopted exclusively in the presence of marked curvatures. When intercourse becomes too painful, or even impossible to practice, many surgeons resort to the triple incision-excision-transplant surgery.

Basically, it involves the practice of making an incision at the level of the plaque, removing the mass and transplanting a “patch” onto the affected area. The skin of the penis is not touched by the surgery. Several complications can be encountered with this technique.

Implantation of a penile prosthesis

There are various types of prostheses. Some involve an implant of semi-rigid material that replaces the soft components of the penis and thus prevents it from curving. Others, however, are designed to inflate thanks to a specific liquid that is pumped into the structure(hydraulic pumps).

Which intervention to choose

It is up to the physician to judge the situation and choose to proceed in one direction rather than another. After the diagnosis and appropriate investigations, it is possible to make a choice based on:

  • a where the fibrous-cytial tissue cluster is located.
  • By the severity of the symptoms manifested by the patient
  • by the psychological state of the patient (very important for the purpose of a possible surgical option)

Should the choice fall on a particularly invasive surgery, then hospitalization will be necessary. In other cases, the patient might instead be discharged within a single day.

In any case, it is necessary that the curvature of the penis has been stable for some time, and before resuming normal sexual activity, it is recommended to wait 4 to 8 weeks after surgery (but it always depends on each case).


Ask a question
to Dr. Cocci

You will receive a response from Dr. Cocci privately to your e-mail address, and you can consider without obligation whether to book the specialist visit.

    Book a visit or consultation

    I receive at and Facilities in Milan, Florence, Prato.

    Book your first visit or specialist consultation at the location nearest you.

    For patients living abroad, an initial consultation can also be requested remotely through the contact form.

    Florence | Matteotti Medical Group

    Giacomo Matteotti Avenue, 42
    50132 – Florence (FI)
    Phone: 055 570224

    Florence Castle | Villa Donatello

    Attilio Ragionieri Street, 101
    50019 – Sesto Fiorentino (FI)
    Phone: 055 50975

    Prato | Life Medical Practice

    141 Republic Avenue
    59100 – Prato (PO)
    Phone: 0574 583501

    Milan | Columbus Clinic Center

    Via Michelangelo Buonarroti, 48
    20145 – Milan (MI)
    Phone: 02 480801

    Dr. Andrea Cocci

    urologist and andrologist

    The choice to devote my professional life to urology and in particular to andrologic and reconstructive surgery is the result of a deep passion for anatomy, the art of surgery and in general the diagnostic therapeutic process leading to patient recovery. Oncological pathology, infertility, erectile dysfunction, penile disease, or simply prostate disorders irretrievably afflict not only the individual but also the couple dimension.

    Received at:
    Florence, Milan, Prato

    Dr. Andrea Cocci
    Urologist and andrologist

    I have full conviction that listening to the patient, carping about his or her needs, and assessing his or her expectations is the only way to establish a therapeutic program of success and satisfaction for both physician and patient.